AP Top News at 10:45 p.m. EST

Overnight Headlines

Here's the latest overnight headlines.

U.S. stocks ended mixed Wednesday, with the Dow Jones Industrial Average closing at a record high. The S&P 500 and Nasdaq Composite also gained ground, but the Russell 2000 index of small-cap stocks fell.

Breaking news: A powerful earthquake has struck central Italy, causing widespread damage and injuries. The U.S. Geological Survey reports that the quake had a preliminary magnitude of 6.6 and was centered near the town of Amatrice.

World News

In other news, the Syrian government has agreed to a U.N.-mediated ceasefire, but rebels are skeptical. The ceasefire is set to begin on Friday.

The European Union is set to impose sanctions on Russia over its annexation of Crimea. The sanctions are expected to target Russian individuals and companies.

Business News

In business news, Apple has released its latest iPhone, the iPhone 7. The new phone has a number of new features, including a faster processor, a better camera, and a longer battery life.

Amazon has announced plans to hire 100,000 new employees in the United States. The new hires will work in a variety of positions, including customer service, warehouse, and delivery.

Sports News

In sports news, the U.S. Open tennis tournament is underway. The tournament is one of the four Grand Slam tournaments in tennis.

The NFL season is also underway. The first game of the season was played on Thursday night between the Denver Broncos and the Carolina Panthers.